報 告 人：胡譯丹 副教授

報告題目：Engineering thickness-controllable catalyticbiofilm and its biotechnology applications

報告時間：2023年12月27日 16:00-16:30

報告地點：生科院1#109會議室

主辦單位：生命科學學院、科學技術研究院

報告人簡介：

胡譯丹，中國地質大學（武漢）環境學院副教授。博士畢業于新加坡南洋理工大學環境科學與工程研究中心。胡譯丹博士長期從事微生物被膜的合成生物學改造，尤其將光遺傳學用于生物膜調控方面開展了一系列原創工作。相關工作發表在 Science Advances, ChemSusChem, Chemical Communications等期刊。胡譯丹博士現擔任 BioDesign Research青年編委。

報告摘要：

　　Biofilms have beendemonstrated as promising biocatalysts for applications in environmental andindustrial biotechnologies. One of the most important factors influencingoverall performance of biofilm-mediated biocatalysis is biofilm thickness. Itis highly desirable to maintain the biofilm thickness within an optimal rangewhich allows for efficient mass transfer and biocatalysis. Optogenetic toolsare ideal for controlling biofilm thickness, as light is non-invasive, easilycontrollable and cost-efficient. I will present our work to engineer lightresponsive biofilms whose development can be modulated by light through lightresponsive c-di-GMP gene circuits in which the bacterial cells sense light toadjust its biofilm formation by regulating the c-di-GMP level. The engineeredbiofilms with a controllable thickness show promise in efficient and robustbiofilm-mediated bioprocesses. I will also briefly discuss the potentialapplication of light-responsive biofilms in bioelectricity generation, chemicalsynthesis and biofouling mitigation.